Invention Grant
- Patent Title: Process for preparing 2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicy-clo[2.2.1]heptane
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Application No.: US16770969Application Date: 2018-12-06
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Publication No.: US11897895B2Publication Date: 2024-02-13
- Inventor: Michael Rack , Stefan Benson , Bernd Wolf , Roland Goetz
- Applicant: BASF AGRO B.V.
- Applicant Address: NL Arnhem
- Assignee: BASF AGRO B.V.
- Current Assignee: BASF AGRO B.V.
- Current Assignee Address: NL Arnhem
- Agency: MARSHALL, GERSTEIN & BORUN LLP
- Priority: EP 207716 2017.12.15
- International Application: PCT/EP2018/083807 2018.12.06
- International Announcement: WO2019/115347A 2019.06.20
- Date entered country: 2020-06-09
- Main IPC: C07D493/18
- IPC: C07D493/18
![Process for preparing 2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicy-clo[2.2.1]heptane](/abs-image/US/2024/02/13/US11897895B2/abs.jpg.150x150.jpg)
Abstract:
This invention relates to a process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (I), any one of its individual enantiomers or any non-racemic mixture thereof any one of its individual enantiomers or any non-racemic mixture thereof, comprising the steps of (a) reacting (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II), any one of its individual enantiomers or any non-racemic mixture thereof (as defined in the description) with elemental sodium to form a sodium salt of the formula (III), any one of its individual enantiomers or any non-racemic mixture thereof (as defined in the description), and (b) reacting said sodium salt (III) with a 2-Methylbenzyl compound of the formula (IV) wherein X is a leaving group, wherein the steps (a) and (b) are conducted in the presence of at least one substantially anhydrous inert organic solvent.
Public/Granted literature
- US20210163496A1 PROCESS FOR PREPARING 2-EXO-(2-METHYLBENZYLOXY)-1-METHYL-4-ISOPROPYL-7-OXABICYCLO[2.2.1]HEPTANE Public/Granted day:2021-06-03
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