A display panel driving method, a display device and a driving device are provided. The method obtains a standard driving voltage value of a target pixel when a subject display content is being displayed and a target compression unit corresponding to the target pixel, determines a target compensation curve parameter from compressed de-Mura data corresponding to the target compression unit according to the standard driving voltage value, determines an effective driving voltage value of the target pixel when the subject content is being displayed according to a position information where the target pixel is in the target compression unit and the target compensation curve parameter, and drives the display panel according to the effective driving voltage. This method could correctly identify the corresponding decompression data and thus the decompressed data could be close to the actual data. This raises the decompression accuracy of decompressing the de-Mura data.