A system includes an image guidance system with a memory with computer executable instruction, a processor configured to execute the computer executable instructions, and a display. The computer executable instructions cause the processor to: receive a three-dimensional model of vasculature from an ultrasound imaging system, receive a real-time optical feed of an interior of a cavity from an optical camera-based guidance system, receive a first tracking signal indicative of a first spatial location of a probe of the ultrasound imaging system, receive a second spatial location of the optical camera-based guidance system, and overlay the optical feed with the three-dimensional model based on the first and second tracking signals. The display is configured to visually present the optical feed with the three-dimensional model overlaid thereover.