A fluid handling system includes a pressure exchanger (PX) configured to receive a first fluid at a first pressure and a second fluid at a second pressure and exchange pressure between the first fluid and the second fluid. The system further includes a condenser configured to provide corresponding thermal energy from the first fluid to a corresponding environment. The system further includes a receiver to receive the first fluid output by the PX. The receiver forms a chamber to separate the first fluid into a first gas and a first liquid. The system further includes a first booster to increase pressure of a portion of the first gas to form the second fluid at the second pressure and provide the second fluid at the second pressure to the PX.