Invention Grant
- Patent Title: PD-1 targeted IL-15/IL-15Rα Fc fusion proteins with improved properties
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Application No.: US17067508Application Date: 2020-10-09
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Publication No.: US11932675B2Publication Date: 2024-03-19
- Inventor: John Desjarlais , Matthew Bernett , Michael Hedvat , Rajat Varma , Suzanne Schubbert , Christine Bonzon , Rumana Rashid , Juan Diaz , Patrick Holder , Christine Huang
- Applicant: Genentech, Inc. , Xencor, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: GENENTECH, INC.,XENCOR, INC.
- Current Assignee: GENENTECH, INC.,XENCOR, INC.
- Current Assignee Address: US CA South San Francisco; US CA Pasadena
- Agency: HALEY GUILIANO LLP
- Agent Karen Mangasarian; Brian M. Gummow
- Main IPC: C07K14/00
- IPC: C07K14/00 ; A61P35/00 ; C07K14/54 ; C07K16/28 ; A61K38/00
Abstract:
The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.
Public/Granted literature
- US20210230243A1 PD-1 TARGETED IL-15/IL-15RALPHA FC FUSION PROTEINS WITH IMPROVED PROPERTIES Public/Granted day:2021-07-29
Information query
