- 专利标题: Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137
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申请号: US16769299申请日: 2018-12-04
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公开(公告)号: US11952422B2公开(公告)日: 2024-04-09
- 发明人: Shun Shimizu , Shu Wen Samantha Ho , Naoka Hironiwa , Mika Sakurai , Taro Miyazaki , Tomoyuki Igawa
- 申请人: Chugai Seiyaku Kabushiki Kaisha
- 申请人地址: JP Tokyo
- 专利权人: Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人: Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址: JP Tokyo
- 代理机构: Fish & Richardson P.C.
- 优先权: JP 17233104 2017.12.05
- 国际申请: PCT/JP2018/044493 2018.12.04
- 国际公布: WO2019/111871A 2019.06.13
- 进入国家日期: 2020-06-03
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; C07K16/30 ; C40B30/04
摘要:
Antigen-binding domains that are capable of binding to CD3 and CD137 but do not bind to CD3 and CD137 at the same time and methods of using the same are provided. Methods to obtain antigen binding domains which bind to two or more different antigen more efficiently are also provided.
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