- 专利标题: Methods directed to crystalline biomolecules
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申请号: US16494165申请日: 2018-03-14
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公开(公告)号: US11958882B2公开(公告)日: 2024-04-16
- 发明人: Rizwan Sharnez , William Trieu , Marc A. Caporini , Ron C. Kelly , Neill Burt , Laura Nicholson , Twinkle R. Christian
- 申请人: AMGEN INC.
- 申请人地址: US CA Thousand Oaks
- 专利权人: AMGEN INC.
- 当前专利权人: AMGEN INC.
- 当前专利权人地址: US CA Thousand Oaks
- 代理商 Melissa E. Karabinis
- 国际申请: PCT/US2018/022387 2018.03.14
- 国际公布: WO2018/170098A 2018.09.20
- 进入国家日期: 2019-09-13
- 主分类号: C30B7/10
- IPC分类号: C30B7/10 ; A61K39/395 ; B01J8/20 ; B01J8/38 ; C07K1/30 ; C30B7/00 ; C30B30/04 ; G01N24/08 ; C30B30/00 ; C30B30/02 ; G01N24/00 ; G01R33/20 ; G01R33/46
摘要:
Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.
公开/授权文献
- US20200157141A1 METHODS DIRECTED TO CRYSTALLINE BIOMOLECULES 公开/授权日:2020-05-21
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