An antenna structure and a high-frequency multi-band wireless communication terminal are provided. The antenna structure includes: a metal plate, on which a first accommodation groove is provided; an antenna unit, including a radiating patch and a first coupling piece; and a radio frequency module, where the radio frequency module is disposed on a first side of the metal plate, and the radio frequency module is electrically connected to the radiating patch; where at least one of the radiating patch and the first coupling piece is disposed inside the first accommodation groove, the radiating patch is insulated from the metal plate, the first coupling piece is insulated from the metal plate, the radiating patch and the first coupling piece are disposed opposite to each other, the radiating patch is insulated from the first coupling piece, the first coupling piece is located between the radiating patch and the radio frequency module.