Systems, methods, and software for selecting a network slice for User Equipment (UE) based on a use case specified by the UE. In one embodiment, a slicing policy manager is implemented in a network that is partitioned into a plurality of network slices. The slicing policy manager receives a policy request for the UE, identifies a use case identifier in the policy request that indicates a use case specified by the UE, generates a use case slice selection policy configured to select a network slice from the plurality of network slices based on the use case specified by the UE, and initiates transmission of the use case slice selection policy to a slice selection manager. The slice selection manager may then select a network slice for the UE based on the policy.