Appliances for intraoral delivery of agents are provided. In some embodiments, an appliance includes a shell having an inner surface and an outer surface, the inner surface defining a plurality of tooth-receiving cavities configured to apply a repositioning force to a patient's teeth, and the outer surface oriented away from the patient's teeth. The appliance can also include a reservoir integrally formed in the outer surface of the shell, the reservoir being configured to store at least one agent. The appliance can further include a membrane covering at least a portion of the reservoir to control release of the agent into an intraoral cavity of the patient. The membrane can include a plurality of pores that are configured to open based at least in part on a temperature of the patient's intraoral cavity to allow the at least one agent to pass therethrough.