- 专利标题: Nanobody target GCC and uses in chimeric antigen receptor cell therapy
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申请号: US17821706申请日: 2022-08-23
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公开(公告)号: US11970548B2公开(公告)日: 2024-04-30
- 发明人: Zhiyuan Cao , Yuzhe Peng , Lei Xiao , Zhao Wu , Le Tian
- 申请人: Innovative Cellular Therapeutics Holdings, Ltd. , Innovative Cellular Therapeutics, Inc.
- 申请人地址: KY MD George Town
- 专利权人: Innovative Cellular Therapeutics Holdings, Ltd.,Innovative Cellular Therapeutics, Inc.
- 当前专利权人: Innovative Cellular Therapeutics Holdings, Ltd.,Innovative Cellular Therapeutics, Inc.
- 当前专利权人地址: KY George Town; US MD Rockville
- 代理机构: Lee & Hayes, P.C.
- 主分类号: C12P21/08
- IPC分类号: C12P21/08 ; A61K35/17 ; A61K39/395 ; A61K47/68 ; A61P35/00 ; C07K14/725 ; C07K16/28 ; C07K16/30 ; C07K16/40 ; A61K38/00
摘要:
The compositions and methods described herein are directed to treating solid tumors using CAR T therapy and/or antibodies targeting GCC. The compositions include CAR comprising an extracellular domain that binds GCC.
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