Invention Grant
- Patent Title: Compositions and methods for screening and identifying clinically aggressive prostate cancer
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Application No.: US16071289Application Date: 2017-01-20
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Publication No.: US11971411B2Publication Date: 2024-04-30
- Inventor: Curtis Huttenhower , Travis Gerke , Christopher Sweeney , Lorelei Mucci , Gwo-Sho Mary Lee , Daniela Bornigen , Xiaodong Wang , Svitlana Tyekucheva , Kristina Jordahl
- Applicant: DANA-FARBER CANCER INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Applicant Address: US MA Boston
- Assignee: DANA-FARBER CANCER INSTITUTE, INC.,PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Current Assignee: DANA-FARBER CANCER INSTITUTE, INC.,PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Current Assignee Address: US MA Boston; US MA Cambridge
- Agency: Mueting Raasch Group
- International Application: PCT/US2017/014362 2017.01.20
- International Announcement: WO2017/127696A 2017.07.27
- Date entered country: 2018-07-19
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/574
Abstract:
The present invention provides methods for screening and diagnosing prostate cancer based on a correlation between cancer cell growth, cancer lethality or recurrence and the expression level of ZFP36 or NEDD9 and PTEN in conjunction with ZFP36. The disclosure also provides methods for screening and diagnosing prostate cancer based on a correlation between cancer lethality and the genotype of rs1910301 SNP. Also provided are methods for treating prostate cancer comprising providing a treatment or monitoring based on the expression level of ZFP36, the expression level of NEDD9, and the expression level of ZFP36 in conjunction with PTEN levels or the genotype of rs1910301 SNP.
Public/Granted literature
- US20200041515A1 COMPOSITIONS AND METHODS FOR SCREENING AND IDENTIFYING CLINICALLY AGGRESSIVE PROSTATE CANCER Public/Granted day:2020-02-06
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