A multimedia system and a multimedia operation method are provided. The multimedia system includes a signal encoder, a screen, multiple loudspeakers, a processor, and an amplifier circuit. The signal encoder encodes an image signal, an audio signal, and an audio enhancement signal to provide a multimedia signal. The image signal is divided into multiple regional image signals based on multiple display regions. The audio signal includes multiple regional audio signals corresponding to the regional image signals. The processor extracts the image signal, the regional audio signals, and the audio enhancement signal from the multimedia signal and controls the screen to display the image signal. The amplifier circuit adjusts the regional audio signals in response to the audio enhancement signal and provides the adjusted regional audio signals to the loudspeakers.