- 专利标题： Growth hormone receptor antagonists and fusion proteins thereof
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申请号： US16954902申请日： 2018-12-20
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公开(公告)号： US11981719B2公开(公告)日： 2024-05-14
- 发明人: Soon Jae Park , Jaehyeong Ko , Sun-Ah You , Sang Hoon Yun
- 申请人： Alteogen, Inc.
- 申请人地址： KR Daejeon
- 专利权人： Alteogen, Inc.
- 当前专利权人： Alteogen, Inc.
- 当前专利权人地址： KR Daejeon
- 代理机构： Cooley LLP
- 优先权： KR 20170176493 2017.12.20 KR 20180147700 2018.11.26
- 国际申请： PCT/KR2018/016311 2018.12.20
- 国际公布： WO2019/125002A 2019.06.27
- 进入国家日期： 2020-06-17
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K47/62 ; C07K14/61 ; C07K14/81
摘要：
The present invention relates to a growth hormone receptor antagonist comprising a growth hormone variant which is modified by substitution of one or more amino acids of growth hormone. Further, the growth hormone receptor antagonist of the present invention may further comprise a long-acting carrier which is fused to the growth hormone variant. The growth hormone receptor antagonist may have strong binding potency to growth hormone receptor and may exhibit a long-lasting antagonistic action.
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