The present disclosure discloses a novel omniphobic, paper-based, smart bandage (OPSB) devices, and the methods to make and use the omniphobic, paper-based, smart bandage devices. The OPSB device of the present disclosure provides a simple, low-cost, and non-invasive strategy to monitor open wound status wirelessly. This disclosure also provides the demonstration of in-vivo early detection and monitoring of pressure ulcers using wireless smart bandages.