According to an aspect there is provided a method for automatic maintenance of a dialysis system. The dialysis system includes a plurality of filter sections where each filter section includes a blood flow channel, a dialysate flow channel, and a membrane separating the blood flow channel from the dialysate flow channel and having a plurality of pores through which substances are exchanged between a blood flow in the blood flow channel and a dialysate flow in the dialysate flow channel. The method includes determining, for each filter section of the plurality of filter sections, whether a maintenance criterion is fulfilled. The method also includes triggering a maintenance event for a filter section of the plurality of filter sections for which the maintenance criterion is fulfilled. The method also includes executing the maintenance event and optionally administering a thrombolytic agent to the blood flow channel of the filter section.