The present disclosure provides a system and method for medical image visualization. The method may include obtaining original image data of a subject, the original image data including a first region of interest (ROI) and a second ROI. The method may also include generating first image data associated with the first ROI according to a first instruction, and causing the first ROI to be displayed on a display device as a first image based on the first image data. The method may further include generating, according to a second instruction, second image data corresponding to a target region that includes the second ROI, updating the first image data based on the second image data, and causing the second ROI to be displayed on the display device as a second image based on the updated first image data.