- 专利标题： Conjugate of a tubulysin analog with branched linkers
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申请号： US16759175申请日： 2017-12-31
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公开(公告)号： US11998584B2公开(公告)日： 2024-06-04
- 发明人: Robert Yongxin Zhao , Qingliang Yang , Yuanyuan Huang , Linyao Zhao , Shun Gai , Hangbo Ye , Jun Lei , Yifang Xu , Mingjun Cao , Huihui Guo , Junxiang Jia , Qianqian Tong , Wenjun Li , Xiaomai Zhou , Hongsheng Xie , Lu Bai , Xiang Cai , Xiaotao Zhuo , Xiuzheng Zhang , Jun Zheng
- 申请人： Hangzhou DAC Biotech Co., Ltd.
- 申请人地址： CN Hangzhou
- 专利权人： Hangzhou DAC Biotech Co., Ltd.
- 当前专利权人： Hangzhou DAC Biotech Co., Ltd.
- 当前专利权人地址： CN Hangzhou
- 代理机构： BUCHANAN, INGERSOLL & ROONEY PC
- 国际申请： PCT/CN2017/120454 2017.12.31
- 国际公布： WO2019/127607A 2019.07.04
- 进入国家日期： 2020-04-24
- 主分类号： A61K38/07
- IPC分类号： A61K38/07 ; A61K45/06 ; C07K5/117
摘要：
The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
公开/授权文献
- US20200276261A1 A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS 公开/授权日：2020-09-03
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