Invention Grant
- Patent Title: Neuroactive steroids and their methods of use
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Application No.: US18334189Application Date: 2023-06-13
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Publication No.: US11999765B2Publication Date: 2024-06-04
- Inventor: Maria Jesus Blanco-Pillado , Francesco G. Salituro , Marshall Lee Morningstar
- Applicant: SAGE THERAPEUTICS, INC.
- Applicant Address: US MA Cambridge
- Assignee: Sage Therapeutics, Inc.
- Current Assignee: Sage Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Honigman LLP
- Agent Andrew N. Weber; Jonathan P. O'Brien
- Main IPC: C07J43/00
- IPC: C07J43/00 ; C07J41/00

Abstract:
Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R19, R5, R3a, R1a, R1b, R2a, R2b, R4a, R4b, R6a, R6b, R7a, R7b, R11a, R11b, R12a, R12b, R18, RD, and q are defined herein. L is selected from the group consisting of: wherein A indicates the point of attachment at C17 and wherein X is selected from the group consisting of —C(O)N(R55a)(R55b), —N(R55a)(R55b), —N(R55b)C(O)(R55a), and R55C wherein R55c is carbon-bound substituted or unsubstituted heteroaryl or substituted or unsubstituted aryl. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.
Public/Granted literature
- US20230322848A1 NEUROACTIVE STEROIDS AND THEIR METHODS OF USE Public/Granted day:2023-10-12
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