A picking and dispatching system includes: a control center, terminals carried by users, and handling devices. The control center is configured to: determine an item storage space of a to-be-picked item included in each of to-be-picked orders, and plan paths for each user and each handling device to reach the item storage space; match, according to each planned path and assigned to-be-picked order, a user and a handling device for picking, to determine to-be-selected tasks, and determine a moment at which a user and a handling device cooperate to pick from the item storage space; determine a target task from the to-be-selected tasks, and send the target task to a terminal and a handling device; assign, according to the target task sent to the handling device, a to-be-picked order to the handling device, and update the stored assignment result of the to-be-picked orders.