- Patent Title: Hexahydropyrrolo[3,4-c]pyrrole derivatives useful as LOX inhibitors
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Application No.: US16972335Application Date: 2019-06-05
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Publication No.: US12018029B2Publication Date: 2024-06-25
- Inventor: Leo Leung , Kiri North , Deborah Smithen , Mohammed Aljarah , Michael Brown , Ben Ayers , Dan Niculescu-Duvaz , Caroline Springer
- Applicant: THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
- Applicant Address: GB London
- Assignee: The Institute of Cancer Research: Royal Cancer Hospital
- Current Assignee: The Institute of Cancer Research: Royal Cancer Hospital
- Current Assignee Address: GB London
- Agency: Meunier Carlin & Curfman LLC
- Priority: GB 09295 2018.06.06
- International Application: PCT/GB2019/051552 2019.06.05
- International Announcement: WO2019/234418A 2019.12.12
- Date entered country: 2020-12-04
- Main IPC: A61P35/00
- IPC: A61P35/00 ; C07D487/04
![Hexahydropyrrolo[3,4-c]pyrrole derivatives useful as LOX inhibitors](/abs-image/US/2024/06/25/US12018029B2/abs.jpg.150x150.jpg)
Abstract:
The disclosure relates to compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein X1 and X5 is each selected from CR1 or N; X2, X3 and X4 is each selected from CR1, CR2 or N, provided at least one of X2, X3 and X4 is CR2 and provided only one of X1, X2, X3, X4 and X5 can be N. R1, R2, R3, R4, R5, L1, L2 and L3 are as defined herein. Compounds according to Formula (I) are pharmacologically effective as lysyl oxidase (LOX) inhibitors and are believed to be useful in the treatment of, for instance, cancer.
Public/Granted literature
- US20210238179A1 HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES USEFUL AS LOX INHIBITORS Public/Granted day:2021-08-05
Information query
IPC分类:
A | 人类生活必需 |
A61 | 医学或兽医学;卫生学 |
A61P | 化合物或药物制剂的特定治疗活性 |
A61P35/00 | 抗肿瘤药 |