Invention Grant
- Patent Title: Combination of a ubiquitin-conjugating enzyme complex inhibitor and antihypertensive and/or hypoglycemic drugs in diabetic kidney disease
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Application No.: US17043955Application Date: 2019-03-28
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Publication No.: US12036201B2Publication Date: 2024-07-16
- Inventor: Loreto Gesualdo , Paola Pontrelli
- Applicant: UNIVERSITÀ DEGLI STUDI DI BARI ALDO MORO
- Applicant Address: IT Bari
- Assignee: UNIVERSITÀ DEGLI STUDI DI BARI ALDO MORO
- Current Assignee: UNIVERSITÀ DEGLI STUDI DI BARI ALDO MORO
- Current Assignee Address: IT Bari
- Agency: Greer, Burns & Crain, Ltd.
- Agent Gregory P. Einhorn
- Priority: IT 2018000004126 2018.03.30
- International Application: PCT/IB2019/052525 2019.03.28
- International Announcement: WO2019/186442A 2019.10.03
- Date entered country: 2020-09-30
- Main IPC: A61K31/345
- IPC: A61K31/345 ; A61K31/277 ; A61K31/351 ; A61K31/403 ; A61P3/10 ; A61P13/12
Abstract:
The present invention relates to a composition comprising at least one inhibitor of the enzymatic complex conjugating ubiquitin Ubc13/Uev1a and at least one anti-hypertensive agent inhibiting the renin-angiotensin-aldosterone system and/or a hypoglycemic agent. Medical uses and pharmaceutical compositions comprising this composition also fall within the scope of the present invention. In particular, this composition can be used for the treatment or prevention of the renal fibrotic damage, in particular in patients suffering from diabetes.
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