Invention Grant
- Patent Title: BCMA CAR-T cells with enhanced activities
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Application No.: US17183689Application Date: 2021-02-24
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Publication No.: US12036243B2Publication Date: 2024-07-16
- Inventor: Regina Junhui Lin , Siler Panowski , Cesar Adolfo Sommer , Thomas John Van Blarcom , Barbra Johnson Sasu , Arun Balakumaran
- Applicant: Allogene Therapeutics, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Allogene Therapeutics, Inc.
- Current Assignee: Allogene Therapeutics, Inc.
- Current Assignee Address: US CA South San Francisco
- Main IPC: A61K35/17
- IPC: A61K35/17 ; A61P35/00 ; C07K14/715 ; C07K16/28 ; C12N15/86

Abstract:
Provided here are engineered immune cells that comprise a constitutively active chimeric cytokine receptor (CACCR) and a B-cell maturation antigen (BCMA) specific chimeric antigen receptor (CAR). Also provided herein are engineered immune cells that comprise one or more nucleic acids e.g. a bicistronic vector such as a viral vector that encode the CACCRs and BCMA CARs and engineered immune cells e.g. engineered autologous or allogeneic T cells that express both CACCRs and BCMA CARs from the nucleic acids. When present on chimeric antigen receptor (CAR)-bearing engineered immune cells, the CACCRs allow for increased immune cell activation, proliferation, persistence, and/or potency. Further provided herein are methods of making and using the engineered immune cells described herein, such as methods of treating a disease or condition by administering at least one appropriate dose of the cells to a patient suffering from the condition.
Public/Granted literature
- US20210260118A1 BCMA CAR-T CELLS WITH ENHANCED ACTIVITIES Public/Granted day:2021-08-26
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