Invention Grant
- Patent Title: Constitutively active chimeric cytokine receptors
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Application No.: US16804917Application Date: 2020-02-28
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Publication No.: US12043655B2Publication Date: 2024-07-23
- Inventor: Regina Junhui Lin , Thomas John Van Blarcom , Siler Panowski , Barbra Johnson Sasu
- Applicant: Allogene Therapeutics, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Allogene Therapeutics, Inc.
- Current Assignee: Allogene Therapeutics, Inc.
- Current Assignee Address: US CA South San Francisco
- Main IPC: C07K14/715
- IPC: C07K14/715 ; A61K35/17 ; A61K39/00 ; A61P35/00 ; C07K16/40 ; C12N5/0783 ; C12N7/00 ; C12N15/86
Abstract:
Provided herein are constitutively active chimeric cytokine receptors (CACCRs). When present on chimeric antigen receptor (CAR)-bearing immune cells, such CACCRs allow for increased immune cell activation, proliferation, persistence, and/or potency. Also provided are methods of making and using the CACCRs described herein.
Public/Granted literature
- US20200291090A1 CONSTITUTIVELY ACTIVE CHIMERIC CYTOKINE RECEPTORS Public/Granted day:2020-09-17
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