Methods and systems are provided for detecting artifacts in an electronic signal. In an embodiment, a method is provided comprising: connecting a first input of an electronic device to a first signal line of a signal processing device, such as an amplification device; connecting a second input of the electronic device to a second signal line of the signal processing device, the second signal line being downstream from the first signal line; establishing, based on an observed behavior of a first signal on the first signal line, an expected behavior of a second signal on the second signal line; and determining whether a difference exists between the expected behavior of the second signal and an observed behavior of the second signal. If a difference is detected, the expected behavior of a second signal and the observed behavior of the second signal may be recorded for later analysis.