发明授权
- 专利标题： Substituted halo-quinoline derivatives, method of preparation and applications thereof
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申请号： US16959954申请日： 2019-01-04
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公开(公告)号： US12048693B2公开(公告)日： 2024-07-30
- 发明人: Thierry Passeron , Rachid Benhida , Pascal Dao , Gian Marco De Donatis , Anthony Martin
- 申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique , Université Côte d'Azur
- 申请人地址： FR Paris
- 专利权人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),UNIVERSITÉ CÔTE D'AZUR
- 当前专利权人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),UNIVERSITÉ CÔTE D'AZUR
- 当前专利权人地址： FR Paris; FR Paris; FR Nice
- 代理机构： Parker Highlander PLLC
- 优先权： EP 305005 2018.01.05
- 国际申请： PCT/EP2019/050175 2019.01.04
- 国际公布： WO2019/134975A 2019.07.11
- 进入国家日期： 2020-07-02
- 主分类号： A61K31/4706
- IPC分类号： A61K31/4706 ; A61K39/395 ; A61K45/06 ; A61P35/00 ; A61P35/04 ; C07D215/44 ; C07K16/28
摘要：
The present invention relates to a compound of general formula (I), wherein R1 is OCH2CH2OCH3 or OCH3, R′1 is H or OH, R2 is Cl, F, Br or I, with the proviso that when: R1 is OCH2CH2OCH3 then R′1 is H, R1 is OCH3 then R′1 is OH, its pharmaceutically acceptable salts and/or optical isomers, tautomers, solvates or isotopic variations thereof. The invention also relates to said compounds for use in the treatment of cancer, namely solid tumor cancer, and preferably those selected from melanoma, colon, lung, pancreas, kidney, Merkel carcinoma, squamous cell carcinoma, prostate, breast and bladder. The invention also relates to a pharmaceutical composition comprising said compounds.
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