A system and method for high performance secure access to a trusted platform module on a hardware virtualization platform. Example instructions partition resources of the host system to allocate (a) first resources of the host system for a first virtual machine and (b) second resources of the host system for a second virtual machine, wherein the resources of the host system include memory resources and a trusted platform module, the first virtual machine to run a first guest operating system and the second virtual machine to run a second guest operating system, wherein the first guest operating system is to run in a first isolated environment, the second guest operating system is to run in a second isolated environment; implement a virtual trusted platform module to support encryption for the first virtual machine; and protect the first resources and the second resources from unauthorized access.