- 专利标题： Methods of use of anti-TNFα antibodies
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申请号： US17325036申请日： 2021-05-19
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公开(公告)号： US12055549B2公开(公告)日： 2024-08-06
- 发明人: James Philip O'Connell , John Robert Porter , Alastair Lawson , Tracy Lynn Arakaki , Daniel John Lightwood , Rebecca Jayne Munro
- 申请人： UCB Biopharma SRL , SANOFI
- 申请人地址： BE Brussels
- 专利权人： UCB BIOPHARMA SRL,SANOFI
- 当前专利权人： UCB BIOPHARMA SRL,SANOFI
- 当前专利权人地址： BE Brussels; FR Paris
- 代理机构： MEDLER FERRO WOODHOUSE & MILLS PLLC
- 优先权： GB 10758 2015.06.18
- 分案原申请号： US15736558
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; A61K47/64 ; A61P35/00 ; A61P37/00 ; C07D213/72 ; C07D235/04 ; C07D239/26 ; C07D401/14 ; C07D471/00 ; C07D471/04 ; C07K14/525 ; C07K14/705 ; C07K16/24
摘要：
It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.
公开/授权文献
- US20220074947A1 ANTIBODY EPITOPE 公开/授权日：2022-03-10
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