- 专利标题： MicroRNA-33 inhibitors and use thereof in the treatment of pulmonary fibrosis
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申请号： US17663378申请日： 2022-05-13
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公开(公告)号： US12060555B2公开(公告)日： 2024-08-13
- 发明人: Farida Ahangari , Naftali Kaminski , Carlos Fernandez-Hernando , Raman Bahal
- 申请人： Yale University , University of Connecticut
- 申请人地址： US CT New Haven
- 专利权人： YALE UNIVERSITY,UNIVERSITY OF CONNECTICUT
- 当前专利权人： YALE UNIVERSITY,UNIVERSITY OF CONNECTICUT
- 当前专利权人地址： US CT New Haven; US CT Farmington
- 代理机构： Saul Ewing LLP
- 代理商 Kathryn Doyle; Domingos J. Silva
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K31/713 ; A61P9/10 ; C12N15/11
摘要：
In one aspect, the present disclosure provides a microRNA-33 (miR-33) inhibitor comprising a peptide nucleic acid covalently bound to a pH low insertion peptide. In another aspect, the present disclosure provides a method of treating pulmonary fibrosis in a subject, the method comprising administering to the subject a therapeutically effective amount of the miR-33 inhibitor. In some embodiments, the pulmonary fibrosis is idiopathic pulmonary fibrosis.
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