An electrical stimulation device is provided. The electrical stimulation device includes a power management circuit and an electrical stimulation generation circuit. The power management circuit generates a first voltage and a second voltage to power the electrical stimulation generation circuit. The electrical stimulation generation circuit includes a working-electrode contact and a reference-electrode contact. The electrical stimulation generation circuit generates a first electrical signal at the working-electrode contact and further generates a second electrical signal at the reference-electrode contact. The first electrical signal comprises a plurality of first alternating-current (AC) pulses configuring to for electrically stimulate a target region of a target object.