- 专利标题： RNA target enrichment or depletion of biological samples
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申请号： US17193652申请日： 2021-03-05
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公开(公告)号： US12071616B2公开(公告)日： 2024-08-27
- 发明人: Brian O'Farrell , Claire O'Connell , Kaylyn Oshaben , Daniel Appella
- 申请人： Altratech Limited , The United States of America, as represented by the Secretary, Department of Health and Human Services
- 申请人地址： IE MD Limerick
- 专利权人： Altratech Limited,The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： Altratech Limited,The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： IE Limerick; US MD Rockville
- 代理机构： Brown Rudnick LLP
- 代理商 Adam M. Schoen
- 主分类号： C12N15/10
- IPC分类号： C12N15/10 ; C12Q1/68 ; C12Q1/6806
摘要：
A method of target enrichment or depletion from a sample with an analyte is described. A probe has one of a left-handed PNA pair and a targeting moiety, in which the left-handed PNA pair are a complementary pair of PNAs that are chiral and have a cyclic backbone modification that induces a left-handed helical structure. A capture surface has the other of the left-handed PNA pair; and the left-handed PNA pair bind to hybridize the probe to the capture surface, which may be a magnetic bead.
公开/授权文献
- US20210277387A1 RNA TARGET ENRICHMENT OR DEPLETION OF BIOLOGICAL SAMPLES 公开/授权日：2021-09-09
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