Systems and methods for performing automated quality control for 3D printed molds for orthodontic aligners are described. A method includes generating a plurality of images of the 3D printed mold for the orthodontic aligner using one or more imaging devices, wherein each image of the plurality of images depicts a distinct region of the 3D printed mold for the orthodontic aligner; processing the plurality of images by a processing device to identify one or more types of manufacturing defects of the 3D printed mold for the orthodontic aligner, wherein for each type of manufacturing defect a probability that an image comprises a defect of that type of manufacturing defect is determined; and classifying, by the processing device, the 3D printed mold for the orthodontic aligner as defective based on identifying the one or more types of manufacturing defects.