A motherboard with shockproof, shakeproof and waterproof functions is installed in a cabinet of an electronic device, the motherboard includes a PCB board, wherein front surface of the PCB board is provided with a plurality of structural members, a camera seat unit, an audio seat unit, a functional seat unit, a holder seat and a battery seat with shockproof and shakeproof functions; wherein each of the structural members is dispersedly fixed on a side of the PCB board, wherein the structural member screws and fixes the PCB board inside the cabinet, and wherein each of the seats and the PCB board are coated with waterproof coating.