A method and device with synthetic image generation is included. A method includes acquiring a first image captured by a first camera and second images captured by a second camera having a narrower field of view (FOV) when the second images are captured thereby than that of the first camera when the first image is captured thereby. The method also includes detecting respective blur statuses of each of the second images, selecting a region of the first image on the basis of the region corresponding to a second image, of the second images, selected based on a determination that the blur status of the second image satisfies a blur condition, and generating a synthetic image by synthesizing together the selected region of the first image and the second images not including the selected second image.