- 专利标题： Bispecific chimeric antigen receptors, encoding polynucleotides and use of receptors thereof to treat cancer
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申请号： US18162447申请日： 2023-01-31
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公开(公告)号： US12091459B2公开(公告)日： 2024-09-17
- 发明人: Michael Jensen
- 申请人： Seattle Children's Hospital
- 申请人地址： US WA Seattle
- 专利权人： Seattle Children's Hospital
- 当前专利权人： Seattle Children's Hospital
- 当前专利权人地址： US WA Seattle
- 代理机构： NIXON PEABODY LLP
- 代理商 Suwei Zhu; Linda B. Huber
- 分案原申请号： US15233140 2016.08.10
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K35/17 ; A61K38/00 ; A61K38/17 ; A61K47/68 ; C07K14/705 ; C07K14/71 ; C07K14/725 ; C07K16/46 ; C12N5/0783 ; C12N7/00 ; A61K39/00
摘要：
The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.
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