- 专利标题： Block copolymer and micelle compositions and methods of use thereof
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申请号： US17810591申请日： 2022-07-01
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公开(公告)号： US12091486B2公开(公告)日： 2024-09-17
- 发明人: Jinming Gao , David Boothman , Kejin Zhou , Xiaonan Huang , Yiguang Wang
- 申请人： The Board of Regents of The University of Texas System
- 申请人地址： US TX Austin
- 专利权人： The Board of Regents of The University of Texas System
- 当前专利权人： The Board of Regents of The University of Texas System
- 当前专利权人地址： US TX Austin
- 代理机构： Parker Highlander PLLC
- 分案原申请号： US17198006 2021.03.10
- 主分类号： C08F293/00
- IPC分类号： C08F293/00 ; A61K9/107 ; A61K9/127 ; A61K9/50 ; A61K31/337 ; A61K31/352 ; A61K31/704 ; A61K47/58 ; A61K47/62 ; A61K47/68 ; A61K47/69 ; A61K49/00 ; A61P35/00 ; C07D311/92 ; C08F299/02 ; C08G81/02 ; G01N33/58
摘要：
Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises
wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
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