Systems, apparatus and methods for efficiently operating a chiller plant while minimizing or eliminating the occurrence of centrifugal compressor surge. Taking into account chiller design specifications and current operating conditions, a compressor lift point at which surge is predicted to occur is established. Minima and maxima for various chiller setpoints that avoid or eliminate the occurrence of compressor surge are imposed on setpoints provided by a conventional optimizing chiller controller. The chiller system is operated in accordance with the resultant anti-surge setpoints. Energy savings is realized by modulating coolant tower flow to enable the compressor to operate at near-surge conditions while preventing the onset of actual surge.