In accordance with embodiments of this disclosure, a computational simulation platform comprises a computer-implemented method that includes: generating a mesh or meshless three-dimensional (3D) reconstruction of a vessel lumen and a surface of the vessel lumen based on invasive or non-invasive imaging; assigning material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging; performing balloon pre-dilation, stenting and balloon post-dilation computational simulations with the 3D reconstructed vessel lumen and surface of the vessel lumen; and assessing stent and vessel morphometric and biomechanical measures based on the computational simulations.