A method of operation of a compute system comprising: detecting a skin area in a patient image; generating a normalized image by applying a rescale factor to the skin area; cropping a target pixel array from the normalized image with an acne pimple at the center of the target pixel array; generating an acne type by analyzing the target pixel array including calculating an acne severity score and calculating an area of each acne; and generating a user interface display including an acne indication and the acne severity score for displaying on a device.