A power generation control system of a fuel cell includes: the fuel cell generating a power through a chemical reaction between fuel and air; a consuming device connected to an output terminal of the fuel cell and consuming the power output from the fuel cell; a converter connected between the fuel cell and the consuming device in series or parallel and adjusting an output voltage of the fuel cell; a supply device supplying the air to the fuel cell; a voltage controller controlling the converter on the basis of a required power or current of the fuel cell required to be output; and a supply controller controlling the supply device on the basis of the required power or current of the fuel cell required to be output.