- 专利标题： Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof
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申请号： US17599329申请日： 2020-03-27
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公开(公告)号： US12109179B2公开(公告)日： 2024-10-08
- 发明人: Peter Virsik , Han-Jie Zhou , Marianne Dorothy Sadar , Raymond John Andersen , Kunzhong Jian , Daniel Andrew Golec
- 申请人： ESSA Pharma Inc. , The University of British Columbia , Provincial Health Services Authority
- 申请人地址： CA Vancouver
- 专利权人： ESSA PHARMA INC.,THE UNIVERSITY OF BRITISH COLUMBIA,PROVINCIAL HEALTH SERVICES AUTHORITY
- 当前专利权人： ESSA PHARMA INC.,THE UNIVERSITY OF BRITISH COLUMBIA,PROVINCIAL HEALTH SERVICES AUTHORITY
- 当前专利权人地址： CA Vancouver; CA Vancouver; CA Vancouver
- 代理机构： COOLEY LLP
- 国际申请： PCT/US2020/025545 2020.03.27
- 国际公布： WO2020/198712A 2020.10.01
- 进入国家日期： 2021-09-28
- 主分类号： A61K31/145
- IPC分类号： A61K31/145 ; A61K31/203 ; A61K31/519
摘要：
The present disclosure generally relates to pharmaceutical compositions and combinations comprising an androgen receptor N-terminal domain inhibitor or an inhibitor and a second therapeutically active agent, such as an CDK4/6 inhibitor, a Pin1 inhibitor (inhibitor of peptidyl-prolyl cis/trans isomerases), or an antiandrogen. In particular, the present disclosure relates to pharmaceutical compositions and combinations useful for treatment of various cancers, for example breast cancer and prostate cancer. Further, the present disclosure relates administering an androgen receptor N-terminal domain inhibitor in combination with radiation therapy for treatment of various cancers.
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