- 专利标题： Combination of biomarkers for detecting and evaluating a hepatic fibrosis
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申请号： US17563107申请日： 2021-12-28
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公开(公告)号： US12110551B2公开(公告)日： 2024-10-08
- 发明人: Bénédicte Watelet , Tarik Asselah , Ivan Bieche , Isabelle Catherine Batxelli , Nathalie Jullian , Michel Vidaud , Patrick Marcellin , Daniel Laune , Mohammad Afshar , Eve Mathieu Dupas
- 申请人： BIO-RAD EUROPE GMBH , ARIANA PHARMACEUTICALS , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- 申请人地址： CH Basel
- 专利权人： BIO-RAD EUROPE GMBH,ARIANA PHARMACEUTICALS,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE,ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- 当前专利权人： BIO-RAD EUROPE GMBH,ARIANA PHARMACEUTICALS,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE,ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- 当前专利权人地址： CH Basel; FR Paris; FR Paris; FR Paris; FR Paris
- 代理机构： SALIWANCHIK, LLOYD & EISENSCHENK
- 优先权： FR 51022 2011.02.09
- 分案原申请号： US13984702
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12Q1/6876 ; C12Q1/6883 ; G01N33/576 ; C12Q1/70
摘要：
The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being:
SPP1, and
at least one gene from among A2M and VIM, and
at least one gene from among IL8, CXCL10 and ENG, and
optionally, at least one gene from among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.
SPP1, and
at least one gene from among A2M and VIM, and
at least one gene from among IL8, CXCL10 and ENG, and
optionally, at least one gene from among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.
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