发明授权
- 专利标题： Methods for evaluating tumor cell spheroids using 3D microfluidic cell culture device
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申请号： US17379918申请日： 2021-07-19
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公开(公告)号： US12116636B2公开(公告)日： 2024-10-15
- 发明人: David Barbie , Russell W Jenkins , Cloud P. Paweletz , Elena Ivanova , Amir Aref
- 申请人： Dana-Farber Cancer Institute, Inc.
- 申请人地址： US MA Boston
- 专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人地址： US MA Boston
- 代理机构： Barnes & Thornburg LLP
- 代理商 Aisha R. Hasan
- 主分类号： C12Q1/6886
- IPC分类号： C12Q1/6886 ; C12M3/06 ; C12N1/04 ; C12N9/64 ; C12Q1/6869 ; C12Q1/6881 ; G01N33/50 ; G01N33/58
摘要：
Methods are provided for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods are also described for allowing ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.
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