Proposed is a clothes folding machine, which includes a case, a loading unit disposed at an upper portion of the case and conveying a clothes item gripped by grippers into the case, a folding unit including a longitudinal-line folder folding both sleeves of the clothes item conveyed by the loading unit along longitudinal lines and a transverse-line folder folding the clothes item along transverse lines several times, and an unloading unit disposed at a lower portion of the case and conveying the clothes item folded by the folding unit outside the case.