Proposed is a clothes folding machine, which includes a case, a loading unit disposed at an upper portion of the case, having a plurality of grippers, and conveying a clothes item gripped by the grippers into the case, a folding unit including a longitudinal-line folder folding both sleeves of the clothes item along longitudinal line to overlap and a transverse-line folder configured to fold the clothes item along a transverse line to overlap, and an unloading unit disposed at a lower portion of the case and conveying the clothes item folded by the folding unit outside the case.