Two-stage clasp mechanisms, and related systems and methods, are disclosed herein. In some embodiments, the clasp mechanism includes a first housing portion, a second housing portion configured to connect to the first housing portion, and a locking mechanism configured to secure the first and second housing portions together. The locking mechanism can include a first striker carried by the second housing portion, a second striker movably carried by the first housing portion, and a blocking component movably carried by the second housing portion. The second striker is moveable along a first direction between an engaged position and a disengaged position with the first striker. The blocking component is movable along a second direction at an angle with respect to the first direction between a first position that prevents the first striker from moving and a second position that allows the second striker to move.