The present disclosure provides a method for optimizing transformation of automation equipment in a power distribution network based on reliability, including determining installation states of respective components in the power distribution network and operation criterions for fault isolation, load transfer and fault recovery after a fault occurred in a feeder segment; determining a target function which is a target function for minimizing a total transformation cost of the power distribution network; determining constraint conditions including reliability constraints; establishing an optimization model for evaluating the reliability of the power distribution network based on the reliability constraints in accordance with the target function and the constraints; and solving the established optimization model for evaluating the reliability of the power distribution network based on the reliability constraints to obtain optimal solutions as optimization results of the automation transformation state of the circuit breaker and the switch and the reliability index.