A method of compensating for degradation of a display device includes: determining a reference region including a part of a first display region and a second display region having pixel structures from each other; determining first stress data of first pixels based on a first average luminance value of the first pixels disposed on the part of the first display region; determining second stress data of second pixels based on a second average luminance value of the second pixels disposed on a central region of the second display region; determining third stress data of third pixels based on a third average luminance value of the third pixels disposed on an outer region of the second display region; compensating for degradation of the second pixels based on the first and second stress data, and compensating for degradation of the third pixels based on the first and third stress data.