Invention Grant
- Patent Title: Selective androgen receptor degrader (SARD) ligands and methods of use thereof
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Application No.: US17694183Application Date: 2022-03-14
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Publication No.: US12128026B2Publication Date: 2024-10-29
- Inventor: Ramesh Narayanan , Duane D. Miller , Thamarai Ponnusamy , Dong-Jin Hwang , Yali He , Jayaprakash Pagadala , Christopher C. Coss , James T. Dalton , Charles B. Duke
- Applicant: University of Tennessee Research Foundation , Oncternal Therapeutics, Inc.
- Applicant Address: US TN Knoxville
- Assignee: University of Tennessee Research Foundation,Oncternal Therapeutics, Inc.
- Current Assignee: University of Tennessee Research Foundation,Oncternal Therapeutics, Inc.
- Current Assignee Address: US TN Knoxville; US CA San Diego
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Main IPC: A61K31/404
- IPC: A61K31/404 ; A61K31/403 ; A61K31/416 ; A61K31/4184 ; A61K31/4192 ; A61K31/437 ; A61K31/47 ; A61K31/472 ; A61P35/00

Abstract:
This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
Public/Granted literature
- US20230041951A1 SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE THEREOF Public/Granted day:2023-02-09
Information query
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