Systems and methods are provided for improving safety of one or more vehicle occupants. An example method for improving safety of one or more vehicle occupants includes accessing interior vehicle configuration data that is generated by, or derived from data generated by an interior data collection component, the data representing an interior space of a vehicle; determining, by processing the interior vehicle configuration data, location and orientation of one or more vehicle occupants; selecting a plurality of vehicle safety components to be active based on the location and orientation of the one or more vehicle occupants, and setting the plurality of vehicle safety components to an active state in which the plurality of vehicle safety components are deployed, when an emergency condition is detected.